High Frequency Low Dose Chemotherapy Potentiated by Insulin

As you probably already know, it is sugar that feeds cancer growth. Indeed, PET scans are based on this understanding. In undergoing a PET/CT scan a patient is given radioactive glucose, which is then taken up by the cancer mass. This test is used as a way to evaluate the extent and severity of a cancer in the body.

This relationship of glucose or sugar to cancer is also the basis of IPT with low dose chemotherapy. IPT often involves the administration of a combination of low dose chemotherapy agents which act synergistically as one agent, without suppressing the immune system, and with very few side effects. These can be administered once or twice weekly. How often the treatment is given will be discussed with you.

The regular or standard modern oncology doses of chemotherapy can suppress immune function, which is what we do not want to see in a patient with cancer. This suppression is why patients who receive IV chemotherapy in standard doses often can and often do develop low white blood cell counts, and then require drugs to raise these white blood cell counts.

Furthermore, the combination of low dose chemotherapy agents acts as one single therapy, to lead to cell death of cancer cells. These chemotherapy agents are synergistic with each others in ways of which many physicians are not aware, especially effective when we use them in  low doses.

What you will experience during and after your IPT treatment:

On arrival to the clinic, our medical assistant will take your vital signs. Then either our RN or Dr Godman will put an IV in, or access your port or picc line ( either of these is preferable). Then, our medical assistant will finger prick the tip of your finger to see what your blood sugar is. It is important that  on the day that you are coming for IPT, that you arrive at the office without having eaten anything. This includes coffee or tea or juice. It is also important that you bring in food to eat after your treatment is complete, and also to bring in a bottle of Recharge that you can purchase at most health food stores.

After your initial evaluation, the doctor will administer to you a small amount of regular or fast-acting insulin intravenously. It will be roughly the amount of insulin that your pancreas secretes into your blood after you eat a meal. The intravenous insulin will  over roughly 15-20 minutes lower your blood sugar to roughly about 40% of what it was when you came into the clinic fasting only on water. To give an example, if your fasting blood sugar was 100 on arrival, our goal in administering to you the intravenous insulin is to see your blood sugar drop to the range of 40 or perhaps a little less.

Contrary to what concerns many people, this is in no way dangerous. In fact, most people today have blood sugars that are too high, due to dietary habits, and this puts them at risk for cancer and other chronic diseases.

And we will be monitoring your blood sugar throughout your stay here.

I have been doing this form of cancer therapy for over ten years, and have yet to see any patients develop any problems when their blood sugar is falling. What a patient can sometimes experience as the blood sugar slowly drops into the range of 40 over 15-20 minutes, is an increase in appetite, a slightly increased pulse rate, a little anxiety, and a little perspiration. We are monitoring your blood sugar for the roughly 18 minutes required to lower it to what we call the therapeutic moment, when the fasting blood sugar has with insulin been lowered to a level of roughly 40% of what it was when you entered the clinic that morning. At this therapeutic moment, your cancer cells, wherever they are at in your body, are very  hungry for sugar. They are also very vulnerable to being destroyed by small amounts of chemotherapy, roughly 10% of the dose used in modern oncology. At this therapeutic moment, the doctor will be in the room with you, and will administer in a sequential fashion, a 10% dose of several chemotherapy agents, one after the other.  Frankly, most people, after undergoing this IPT therapy,  wonder what they were so concerned about concerning symptoms and lowering of blood sugar.

After these chemotherapy are given intravenously, we will give you some intravenous glucose or sugar, to raise your blood sugar to what it was when you came in. You will be encouraged to drink your ReCharge (with fruit sugars), and then to eat the  food that you have brought with you. This food needs to have complex carbohydrates and protein, so that it digests and absorbes gradually over several hours, to help keep your blood sugar above 100. It will do this provided you eat more than just a piece of fruit.

We will watch you for a couple of hours after you receive your IPT low dose chemotherapy, to make sure your vital signs remain stable. We will also administer some intravenous fluids with minerals to you over this time.

At the end of this roughly 2 hour period, we will recheck your vital signs, and if you are feeling stronger and your blood sugar is maintaining at aboe 100, we will permit you to leave. For your first and second IPT, we request that you have someone drive you in and be here with you. After the first two treatments, you will be able to drive home yourself 2 hours after your treatment.

Answers to the most commonly asked questions by patients about IPT

1. Will I experience nausea or vomiting after the treatment?

This is possible for a day or so. We give you some intravenous anti-nausea medicine when you receive the IPT, and a prescription for antinausea medicine to fill at a local pharmacy. Retrospectively, I have found that the mild nausea some patients experience within a day after their IPT means tumor die-off ( cancer cells dying because of the low dose chemotherapy, meaning that the low dose chemotherapy agents are killing cancer cells.

2. Will I be fatigued?

A. This again is not uncommon within a day after chemotherapy of any form. The reason we suggest the other therapies we offer is to help alleviate or prevent this fatigue from developing.

3. Will my hair fall out?

A: This is not common with low dose chemotherapy. Hair is a fast growing tissue in the body, and all fast growing tissue, like cells in the intestines, are more susceptible to damage from chemotherapy. Though regular dose chemotherapy often leads to patients losing hair, this is rare in IPT therapy. However, if someone has had full dose chemotherapy prior to  doing IPT, it is possible that there could be some mild hair loss, beause the hair follicles have become sensitized to chemotherapy. However, the benefits of low dose chemotherapy, in my opinion, far outweigh the risks of hair loss.

4. What if I need to go to the hospital?

A: I have very good relationships with a number of local physicians, and have sent patients to the hospital for admission before. There may also be times it is necessary for you to go to the outpatient department at the hospital for a blood transfusion, if you have become anemic. This is more common in patients who have had prior regular dose chemotherapy before coming to the clinic.

5. What about if I need any scans or labs?

A: We can help you to order and do these.

6. Do you do other IV’s that make IPT cancer therapy more effective?

A: Yes. We do intravenous Vitamin C, working up to doses that lead to cancer cell death. We also do intravenous alpha lipoic acid, to support the liver, an important organ for detoxification. We do these therapies on days other than the days of IPT low dose chemotherapy, so they do not interfere with the effectiveness of IPT.

7. Do you suggest other therapies for patients with cancer?

A: Yes. We often will suggest and provide eductional support for food changes so that you can stop making cancer and lower your levels of inflammation. In addition, our doctors will often suggest a comprehensive individualized herbal and nutrient program with high quality products that can be purchased locally or online nationally.

We also might suggest one of the following detoxifcation therapiesfor you: colon hydrotherapy, coffee enemas, castor oil packs, manual lymphatic therapy, ionic foot baths, infrared sauna therapy, and pscyhological counselling relative to the type of stresses that often underlie why we may develop a cancer. These therapies would be available locally through the clinic here.

8. Do you do chemosensitivity testing?

A: Not uncommonly we may suggest this approach. This can be discussed with you when you come to our clinic.

If you have any further questions, we can answer them when we speak in person.

Dr. Zieve

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